Alignment of V2 sequences.

<p>A logo indicating the conservation pattern of the amino acids comprising the V2 loop from position 158 to position 192. 464 V2 sequences from subtype AE viruses were aligned, with larger letters indicating higher conservation. Hydrophobic amino acids are indicated by black letters, charged amino acids by blue (+) and red (-) letters and polar amino acids are colored pink or green. Valine at position 172 is highly conserved in this population (numbering is according the Hxbc2 reference sequence by convention <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108446#pone.0108446-Korber1" target="_blank">[21]</a>).