Model interpretation, mutations leading to PI specific resistance.

<p>Shown are the 30 mutations that have the most diverse effect over the different members of the PI drug class. The figure contains a number of known mutations (e.g. M46L, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002899#pcbi.1002899-Johnson1" target="_blank">[6]</a> A71T, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002899#pcbi.1002899-Johnson1" target="_blank">[6]</a> V82A, <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002899#pcbi.1002899-Johnson1" target="_blank">[6]</a> V82S <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002899#pcbi.1002899-Johnson1" target="_blank">[6]</a>) but also several novel mutations (e.g. G48W, N88G). Values in the cells represent Log FC.