NUP98 loses association with active chromatin domains in post-differentiation IMR90 cells.

<p>Histone modification levels of NUP98 binding genes (-NUP98) and same number of randomly selected genes (-Random) in embryonic stem cells (ESC-) (A) and lung fibroblasts (IMR90-) (B) were plotted. P values were obtained by Mann-Whitney U tests. Randomization was conducted for at least 10 times and similar results were obtained (data not shown). Histone modification levels were calculated from <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003308#pgen.1003308-Lister1" target="_blank">[42]</a>, GSM605321, and GSM605309. Top and bottom of the boxes in the plot are 25^th and 75^th percentile, centerline is the 50^th, and whiskers extend to 1.5 interquartile range from the upper and lower quantile.