Distribution of conservation ranges obtained from the Consurf webserver.

<p>Conservation scores are shown separately for overlap (black line) and non-overlap (grey line) residues for PP interfaces. As a reference, the conservation of all residues on the protein surface (dotted line) is plotted. Negative values indicate residues that are more conserved. Using the Welch t-test the two classes showed a statistically significant difference (p-value<2.2e-16).