Comparative analysis of L-type SALMFamide precursors and putative SALMFamides derived from L-type SALMFamide precursors.

<p><b>A.</b> Multiple sequence alignment of L-type SALMFamide precursors from <i>Strongylocentrotus purpuratus</i> (Sp), <i>Apostichopus japonicus</i> (Aj) and <i>Patiria miniata</i> (Pm). The symbol * labels the positions of residues that are identical in all three sequences, whilst the symbols : and. label the positions of strongly and weakly conserved residues, respectively. Putative neuropeptides that are aligned in all three sequences or that are aligned in the Pm sequence and the Sp or Aj sequences are labelled: Align L1, Align L2 and Align L3. <b>B.</b> Comparison of the C-terminally aligned sequences of putative SALMFamides derived from the L-type SALMFamide precursors in Sp, Aj and Pm. Hydrophobic residues are shown in red, hydrophilic residues are shown in green and basic residues are shown in pink. The putative C-terminal amide group is denoted as “a”.