DIDS (400 µM) causes mitochondrial swelling and cristae reduction.

<p>DIDS treated mitochondria were longer, fewer in number, and had markedly reduced cristae density. (<b>A</b>) Sample TEM images of mitochondria from neurons treated as indicated for 24 hrs. Arrow indicates “ballooning” of outer mitochondrial membrane (OMM). (<b>B</b>) Summary of mitochondrial morphology-related parameters from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060804#pone-0060804-g004" target="_blank">Fig. 4A</a>. (<b>C</b>) Summary of cristae morphology-related parameters from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060804#pone-0060804-g004" target="_blank">Fig. 4A</a>. Data are mean ± SEM. Asterisks (*) indicate significant difference from normoxic controls (<i>p</i><0.05).