Intracellular cytokine production in CD8 T cells is improved by Biojector® delivery.

<p>The boxplots represent a side-by-side comparison of the median magnitude, 25^th and 75^th quartiles, for CD8 T cell intracellular cytokine staining in Biojector®- (blue) and N/S- (red) primed groups at baseline (Day 0), after two DNA injections (Weeks 6 and 8), post prime (Weeks 10, 12 and 24) and post rAd5 boost (Weeks 28, 30, 42, and 94). The response to EnvA and Gag peptide pools are shown. DNA (weeks 0, 4, and 8) and rAd5 (week 24) study injection timepoints are noted on the X-axis as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0059340#pone-0059340-g003" target="_blank">Figure 3</a>. Subjects from both rAd5 dose levels are plotted together. * = p<.05; ** = p<.01; *** = p<.001 (Wilcoxon Rank Sum test).