CADM1 is responsible for mast cell adhesion to airway smooth muscle cells.

<p>HMC-1 cells and HLMCs were transduced with SP4, SP1, CADM1 shRNA, GFP or luciferase control shRNA using adenoviral delivery, followed by the study of adhesion to HASMCs. A) Downregulation of CADM1 significantly reduced HMC-1 cell adhesion to HASMCs (n = 4), but overexpression of the SP4 or SP1 isoforms did not increase it. *p<0.05, **p<0.01 compared to luciferase control shRNA. B) Downregulation of CADM1 using shRNA reduced adhesion of HLMCs (n = 4) to HASMCs (n = 3, except for luciferase control shRNA where n = 2), but overexpression of SP4 or SP1 did not increase it. *p<0.05 compared to CADM1 shRNA.