Amino acid sequence conservation of calmodulin binding, amino terminal (NSCaTE) and carboxyl terminal (Pre-IQ/IQ) motifs in L-type Cav1 channels.

<p>(A) Running window of amino acid similarity of aligned Cav1.2, Cav1.3 and four representative invertebrate L-type channels (red asterisk in B). DI, DII, DIII, DIV are the location of the four major domains, each domain consisting of six transmembrane helices. (B) Multiple alignment of N-terminal sequences illustrating the conservation of NSCaTE and a downstream methionine (Met₂) in L-type channels of coelomate animals. (C) C-terminal sequence alignments illustrating the nearly invariant Pre-IQ/IQ motifs in coelomate animals, with a recognizable “IQ” even in single-celled, <i>Paramecium</i>.