Gbp1-deficient animals are more susceptible to <i>T. gondii</i> infection.

<p>(A) Survival of Gbp1^−/− or C57BL/6 mice s.c. infected with 100 ROP18-deficient (RHΔ<i>ku80</i>Δ<i>rop18</i>) or wild type (RHΔ<i>ku80</i>) parasites. Two independent experiments combined, n = 8 mice per parasite strain for C57BL/6 and n = 10 mice per parasite strain for Gbp1^−/−. (***<i>P</i><0.0005, Gehan-Breslow-Wilcoxon Test). (B) Survival of Gbp1^−/− or Combination of two experiments where n = 8–9 animals per group. (** <i>P</i><0.005, Gehan-Breslow-Wilcoxon Test). (C–F) H&E paraffin sections from the thalamus region of the brains from representative surviving mice (from B) at 60 days post infection. Scale bars = 100 nm.