Irgm3 deficient mice revert the phenotypes of Δ<i>rop18</i> and Δ<i>rop5</i> parasites.

<p>(A) Wild type (C57BL/6) (n = 4 per parasite strain) or Irgm3 deficient (Irgm3^−/−) (n = 4 per parasite strain) mice were infected with 10² luciferase expressing wild type (RHΔ<i>ku80</i>), ROP5 deficient (RHΔ<i>ku80</i>Δ<i>rop5</i>), or ROP18 deficient (RHΔ<i>ku80</i>Δ<i>rop18</i>) parasites by s.c. injection and imaged on indicated days. † denotes one or more death per group. Representative experiment. (B) Survival curves for mice challenged with <i>T. gondii</i> strains as shown. Combination of two experiments (n = 8 animals per group).