<p>a) Insoluble tau analysis, using the DA31-DA9hrp ELISA, does not show any obvious change both in forebrain and hindbrain of treated mice. b) In forebrain, the ratios of insoluble pS202 and pThr231 over total tau are significantly reduced (p = 0.0145, p = 0.0196). The hindbrain analysis does not show any effect.</p
<p>(A) IHC did not reveal marked differences in inflammation-related parameters in forebrain of ACI-...
<p><b>A.</b> AT8 p-tau staining in 3- and 6-month old rTg4510 brain sections. Scale bar = 500 μm. <b...
<p>HRD1 and SEL1L levels in the cerebral cortex of Tg2576 (hemizygous human Swedish double-mutated A...
<p>a) MC1-treated mice display a significant reductions (p = 0.023) in forebrain total tau, while DA...
<p>(A) Fractionation scheme of total brain homogenates from Tau.P301L mice to generate soluble (S1) ...
<p>The CA1 hippocampal region of either MC1 or DA31 treated mice was stained with two different phos...
<p>a) P301L mice were treated with MC1, PHF1 or saline from 7 months of age (200 days): no differenc...
<p>The CA1 hippocampal region of the MC1 treated mice was stained with two different phospho-tau ant...
<p>A) Image analysis of immunohistochemical staining demonstrates no differences in the levels of ea...
<p>(<b>A</b>) Immunohistochemistry (IHC) of coronal brain sections obtained from 17 months-old pR5 m...
<p>Forebrains were stained with antibodies against total Tau (DA9, A, B, C), pSer202 (CP13; D, E, F)...
<p>Analysis by novel object recognition (ORT) (upper panel) and passive inhibitory avoidance (PIA) t...
<p>(<b>A–F</b>) Representative sections depicting CA1 pyramidal neurons from brains of 3xTg-AD<sup>C...
<p>Effect of PHF-13 and PHF-6 (25 mg/Kg i.p.) on <b>A.</b> hippocampal soluble total tau; <b>B.</b> ...
<p>YM3711 at a dose of 100 µg was injected weekly to 15-month old model mice for 6 weeks and the bra...
<p>(A) IHC did not reveal marked differences in inflammation-related parameters in forebrain of ACI-...
<p><b>A.</b> AT8 p-tau staining in 3- and 6-month old rTg4510 brain sections. Scale bar = 500 μm. <b...
<p>HRD1 and SEL1L levels in the cerebral cortex of Tg2576 (hemizygous human Swedish double-mutated A...
<p>a) MC1-treated mice display a significant reductions (p = 0.023) in forebrain total tau, while DA...
<p>(A) Fractionation scheme of total brain homogenates from Tau.P301L mice to generate soluble (S1) ...
<p>The CA1 hippocampal region of either MC1 or DA31 treated mice was stained with two different phos...
<p>a) P301L mice were treated with MC1, PHF1 or saline from 7 months of age (200 days): no differenc...
<p>The CA1 hippocampal region of the MC1 treated mice was stained with two different phospho-tau ant...
<p>A) Image analysis of immunohistochemical staining demonstrates no differences in the levels of ea...
<p>(<b>A</b>) Immunohistochemistry (IHC) of coronal brain sections obtained from 17 months-old pR5 m...
<p>Forebrains were stained with antibodies against total Tau (DA9, A, B, C), pSer202 (CP13; D, E, F)...
<p>Analysis by novel object recognition (ORT) (upper panel) and passive inhibitory avoidance (PIA) t...
<p>(<b>A–F</b>) Representative sections depicting CA1 pyramidal neurons from brains of 3xTg-AD<sup>C...
<p>Effect of PHF-13 and PHF-6 (25 mg/Kg i.p.) on <b>A.</b> hippocampal soluble total tau; <b>B.</b> ...
<p>YM3711 at a dose of 100 µg was injected weekly to 15-month old model mice for 6 weeks and the bra...
<p>(A) IHC did not reveal marked differences in inflammation-related parameters in forebrain of ACI-...
<p><b>A.</b> AT8 p-tau staining in 3- and 6-month old rTg4510 brain sections. Scale bar = 500 μm. <b...
<p>HRD1 and SEL1L levels in the cerebral cortex of Tg2576 (hemizygous human Swedish double-mutated A...