Decrease in the levels of phosphorylated tau detected in the brains of vaccinated mice was not statistically significant.

<p>A) Image analysis of immunohistochemical staining demonstrates no differences in the levels of early-stage phosphorylated tau (AT100) in the hemibrains of vaccinated and control mice. Representative images of hippocampal regions (Hp) from vaccinated and non-vaccinated mice are presented (scale bar 100 µm). B) Image analysis of immunohistochemical staining demonstrates no differences in the levels of mid-stage phosphorylated tau (AT8) in the hemibrains of vaccinated and control mice Representative images of hippocampal regions (Hp) from vaccinated and non-vaccinated mice are presented (scale bar 100 µm). C) Image analysis of immunohistochemical staining demonstrates no differences in the levels of late-stage phosphorylated tau (PHF) in the hemibrains of vaccinated and control mice Representative images of hippocampal regions (Hp) from vaccinated and non-vaccinated mice are presented (scale bar 100 µm).