Induction of antibodies against the HA stalk region following immunization with AdV vector-based vaccines.

<p>Mice (7 animals/group) were immunized with 1203HA, 05HA, H5b, H7HA, H9HA, H7H9b, H1HA, H5b+H7H9b, or ΔE1E3 twice at four-week intervals. Four weeks post-booster inoculation, serum samples were obtained for determining ELISA antibody titers against peptides P1 (a and b) and P2 (c and d) as described under Materials and Methods. The data represent mean titers ± standard deviation (SD) from 7 animals per group. 1203HA, HAd-1203HA; 05HA, HAd-05HA; H5b, HAd-1203HA-05HA; H7HA, HAd-H7HA; H9HA, HAd-H9HA; H7H9b, HAd-H7HA-H9HA; H1HA, HAd-H1HA; H5b+H7H9b; HAd-1203HA-05HA+HAd-H7HA-H9HA; ΔE1E3, HAd-ΔE1E3.