The CD200/CD200R interaction can be blocked by OX131 but not OX110 mAb.

<p>A) Biotinylated rCD4d3+4 (dashed line), CD200R(1) rCD4d3+d4 (solid black line) and CD200R(2) rCD4d3+4 (solid grey line) proteins were immobilized onto streptavidin coated CM5 chips (681, 726, 704 response units respectively). The changes in response units (RU) upon sequential injection of different soluble proteins (boxed and indicated by vertical dots) are shown. (Both antibodies were injected three consecutive times to ensure saturation on the immobilized proteins.) (B) Table showing the increase in response units upon injection of soluble CD200 compared to the pre-injection states for each flow cell. The values for the control rCD4d3+4 indicate the signal due to the high protein content of the CD200 sample.