<p>Amino acid changes in NfxB caused by missense mutations are indicated with the one letter nomenclature. Amino acid substitutions for proline are shown in red, and changes to residues that differ in polarity or charge from the original one are depicted in blue. The secondary structure obtained from the NfxB homology model is shown (Nomenclature H: Helix; T: Turn; -: Coil). The nine α-helices are numbered from α1 to α9.</p
Understanding the molecular mechanisms that correlate pathologies with missense mutations is of crit...
<p>End view (A) and side view (B) of the voluminous model of the GFP-can. Four structure elements ar...
<p>The locations of the seven amino acid replacements in OWFBs are labeled in red line. The seven Ne...
<p>(<b>A</b>) Ribbon diagram of the human NFRKB_WHL domain (residues 370–495) structure is color-cod...
<p>Helix α3 of NFRKB_WHL was aligned with the corresponding helices from some of the structurally si...
<p><b>A,</b> 3D structures of wild-type and mutated TNFR1 proteins. Protein models were generated by...
Here we investigate the structural effects of single amino acid replacements in the extracellular (E...
Escherichia coli NfsB has been studied extensively for its potential for cancer gene therapy by redu...
<p>(A) Ribbon representation of the homology-modeled NfxB dimer based on the TetR-like transcription...
<p>The amino acid number was designated according to the previous nomenclature described in the Huma...
Understanding and predicting molecular cause of disease is one of the major challenges for biology a...
<p>Their active site architecture is shown as surface with amino acid residues represented as lines ...
<p>OWFB substitutions are labeled in black, while parallel substitutions are labeled in red within a...
<p>A) Indicated are the signal peptide (S), fusion peptide (F), transmembrane domain (TM), F1 and F2...
Normal structures are shown in red and the overlaid mutant structures are shown in blue (truncations...
Understanding the molecular mechanisms that correlate pathologies with missense mutations is of crit...
<p>End view (A) and side view (B) of the voluminous model of the GFP-can. Four structure elements ar...
<p>The locations of the seven amino acid replacements in OWFBs are labeled in red line. The seven Ne...
<p>(<b>A</b>) Ribbon diagram of the human NFRKB_WHL domain (residues 370–495) structure is color-cod...
<p>Helix α3 of NFRKB_WHL was aligned with the corresponding helices from some of the structurally si...
<p><b>A,</b> 3D structures of wild-type and mutated TNFR1 proteins. Protein models were generated by...
Here we investigate the structural effects of single amino acid replacements in the extracellular (E...
Escherichia coli NfsB has been studied extensively for its potential for cancer gene therapy by redu...
<p>(A) Ribbon representation of the homology-modeled NfxB dimer based on the TetR-like transcription...
<p>The amino acid number was designated according to the previous nomenclature described in the Huma...
Understanding and predicting molecular cause of disease is one of the major challenges for biology a...
<p>Their active site architecture is shown as surface with amino acid residues represented as lines ...
<p>OWFB substitutions are labeled in black, while parallel substitutions are labeled in red within a...
<p>A) Indicated are the signal peptide (S), fusion peptide (F), transmembrane domain (TM), F1 and F2...
Normal structures are shown in red and the overlaid mutant structures are shown in blue (truncations...
Understanding the molecular mechanisms that correlate pathologies with missense mutations is of crit...
<p>End view (A) and side view (B) of the voluminous model of the GFP-can. Four structure elements ar...
<p>The locations of the seven amino acid replacements in OWFBs are labeled in red line. The seven Ne...