<p>(A) Schematic representation of the position of five CD133 promoters (P1–P5) and exon1s (A–E). (B) Promoter activity of P1, P2, P3, P4 and P5 in human embryonic kidney (HEK) 293 cells (left) and human colon cancer WiDr cells (right) after overexpression of HIF-1α and HIF-2α. (C) Promoter activity of P1, P2, P3, P4, and P5 in HEK293 cells under normoxia and hypoxia for 3 hrs (left) and 24 hrs (right). (D) Promoter activity of P1, P2, P3, P4, and P5 in WiDr cells under normoxia and hypoxia for 24 hrs.</p
<p>(A) Representation of various HREs in the promoter region of vGPCR. vGPCR promoter region was sca...
<p>(A) Luciferase activity of the P5 −98 bp promoter with mutation at the two putative EBSs (mEBS1 a...
Hypoxia regulates many hundreds of genes with important roles in ischemic and neoplastic disorders. ...
CD133 is a cellular surface protein that has been reported to be a cancer stem cell marker, and thus...
<p>(A) Chromatin immunoprecipitation (ChIP) assay showing the binding of O<sub>2</sub>-stable HIF-1α...
<p>(A) Luciferase activities in human embryonic kidney (HEK) 293 cells transfected with a series of ...
<p>(A) P5 −98 bp promoter activity under knockdown of HIF-1α and HIF-2α. (B) P5 −98 bp promoter acti...
Although CD133 is a known representative cancer stem cell marker, its function in tumor aggressivene...
The tumor microenvironment is characterized to be under severe conditions (nutrient shortage, low pH...
<p>Protein expression of PPAR-γ and HIFs (A) as well as pluripotency marker proteins (B) was examine...
The tumor microenvironment is characterized to be under severe conditions (nutrient shortage, low pH...
<p>(A) HIF-1α DNA binding site (HRE) identified on TM9SF4 partial promoter sequence is shown. (B) Ch...
<p>(A) Schematic representation of the hypoxic response element (HRE) binding sites in the PIM2 prom...
<p>Chromatin immunoprecipitation was performed in chromatin lysates from normoxic RCC4 (<b>A</b>) or...
<p>(<b>A</b>) Sequence of the human <i>hepcidin</i> promoter (acc. no. AD000684.1) with two putative...
<p>(A) Representation of various HREs in the promoter region of vGPCR. vGPCR promoter region was sca...
<p>(A) Luciferase activity of the P5 −98 bp promoter with mutation at the two putative EBSs (mEBS1 a...
Hypoxia regulates many hundreds of genes with important roles in ischemic and neoplastic disorders. ...
CD133 is a cellular surface protein that has been reported to be a cancer stem cell marker, and thus...
<p>(A) Chromatin immunoprecipitation (ChIP) assay showing the binding of O<sub>2</sub>-stable HIF-1α...
<p>(A) Luciferase activities in human embryonic kidney (HEK) 293 cells transfected with a series of ...
<p>(A) P5 −98 bp promoter activity under knockdown of HIF-1α and HIF-2α. (B) P5 −98 bp promoter acti...
Although CD133 is a known representative cancer stem cell marker, its function in tumor aggressivene...
The tumor microenvironment is characterized to be under severe conditions (nutrient shortage, low pH...
<p>Protein expression of PPAR-γ and HIFs (A) as well as pluripotency marker proteins (B) was examine...
The tumor microenvironment is characterized to be under severe conditions (nutrient shortage, low pH...
<p>(A) HIF-1α DNA binding site (HRE) identified on TM9SF4 partial promoter sequence is shown. (B) Ch...
<p>(A) Schematic representation of the hypoxic response element (HRE) binding sites in the PIM2 prom...
<p>Chromatin immunoprecipitation was performed in chromatin lysates from normoxic RCC4 (<b>A</b>) or...
<p>(<b>A</b>) Sequence of the human <i>hepcidin</i> promoter (acc. no. AD000684.1) with two putative...
<p>(A) Representation of various HREs in the promoter region of vGPCR. vGPCR promoter region was sca...
<p>(A) Luciferase activity of the P5 −98 bp promoter with mutation at the two putative EBSs (mEBS1 a...
Hypoxia regulates many hundreds of genes with important roles in ischemic and neoplastic disorders. ...