The boundaries of focal deletions that affect the <i>A2BP1</i>, <i>MACROD2</i>, <i>CDKN2A/B</i>, and <i>PTEN</i> genes.

<p>Each of the four panels shows (top) an ideogram of the chromosome on which the featured gene is located and (below) an expanded view of a 4-Mb region centered on the featured gene, showing other genes in the area (location based on the UCSC Genome Browser). If the gene is large enough, the exon-intron structure and/or transcriptional direction of the gene are indicated. For most genes, particularly in panels C and D, the genes are shown as rectangles due to their smaller size. Shown below each expanded region are horizontal bars indicating the extent and boundaries of individual deletions in colon tumors (Panels A and B; <i>A2BP1</i> and <i>MACROD2</i>, respectively), lung tumors (Panel C; <i>CDKN2A/B</i>), or multiple tumor types (Panel D; <i>PTEN</i>). The featured genes in Panels C and D are highlighted in green.