MiR-34a and miR-34c overexpression or PDGFR-α/β silencing decreases migratory and invasive capacity of NSCLC cells.

<p>(<b>a</b>) MiR-34a and -34c enforced expression reduces migratory and invasive capabilities of H1703 cells. (<b>b</b>) PDGFR-α and PDGFR-β silencing reduces migratory and invasive capabilities of Calu-6 cells. RFU= Relative Fluorescence Units. (<b>c</b>) Representative photographs of scratched areas of the confluent monolayer of Calu-6 cells transfected with miR-34a/c or control miRNA (miR-Ctr) at 0h, 12h and 24h after wounding with a pipet tip. Scale bar, 100 μm. The magnification is the same for all the panels. (<b>d</b>–<b>e</b>) PDGFR-α and PDGFR-β overexpression partially rescues migratory and invasive capabilities of Calu-6 cells. * P<0.05.