Loci with highest LOD scores for a given subtype.

<p>The highest LOD scores (shown in bold font), were obtained after including additional families (i.e., n2), as described in <b>Table S2</b> in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067569#pone.0067569.s001" target="_blank">File S1</a></b>.</p>1<p>Previously reported linked region (see <b>Table S1</b> in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067569#pone.0067569.s001" target="_blank">File S1</a></b> for references).</p>*<p>According to permutation tests reached a study-wide significant (i.e., p = 0.02, see <b>Table S9A</b> in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067569#pone.0067569.s003" target="_blank">File S3</a></b>); G1 = 87% white, G1s = 98% white.</p>a<p>An example of loci with highest LOD scores for the first level of subgrouping (intra-family heterogeneity included). This is potentially a shared linked region for all affected siblings in a pedigree regardless of concordance status, for a given subtype (i.e., G1).</p>b<p>Loci with highest LOD scores when only group-specific concordant autistic subjects were maintained (intra-family heterogeneity reduced). It is potentially a linked region only for concordant siblings in a given subtype (i.e., G1s and G4s).