Graphical representation of parametric linkage results suggestive of linkage (LOD score >2.5) in the multiplex AAD families, assuming a rare dominant model.

<p>Graphical representation of parametric linkage results in the multiplex AAD families, assuming a rare dominant model. The LOD/HLOD score is on the y axis and the cM position is on the x axis. The dotted black line shows the LOD/HLOD threshold of 3.0, taken as convincing evidence of linkage. LOD scores are shown with black lines and HLOD scores with grey lines. Linkage peaks of LOD/HLOD greater than 2.5 were observed on chromosomes 7 (upper left panel), 9 (upper right panel) and 18 (lower left panel).