IGF-1 overexpression provided hippocampal neuroprotection 10d after severe brain injury.

<p><b>A)</b> Representative images of the ipsilateral hippocampus from NeuN-immunostained brain sections after severe (1.0 mm) brain injury showing CA-3 neuronal loss (arrow). Scale bar = 200 µm. <b>B)</b> Stereological estimate of total number of CA-3 pyramidal neurons within the dorsal hippocampus (−1.0 to −2.2 mm Bregma) and <b>C)</b> Dentate hilar neuronal counts (total number of cells in 4 sections/animal) from wildtype (WT, open bars) and IGF-1 transgenic (IGF-1Tg, closed bars) mice. IGF-1 overexpression significantly increased neuronal survival in both regions. Data are expressed as mean+SEM. * p<0.05 and # p<0.05 comparing CCI with sham, and <b>!</b> p<0.05 comparing IGF-1Tg to WT.