<p>NHBE (black bars) or NSBE (white bars) cells that reached a well-differentiated state were infected at a MOI of 0.01 with the indicated viruses. At 8 (top panel) and 24 (bottom panel) HPI RNA was harvested and levels of type I and III IFN genes were quantified by qRT-PCR. Results are expressed as fold over mock infected cells and normalized to a housekeeping gene. Significant differences in gene expression between human and swine cells are indicated by * and determined as described in the Material and Methods.</p
<p>MDCK cells were infected with the WT virus or MFPT<sup>r</sup> virus (clone 1) at 1 PFU/cell or m...
<p>Custom human qRT-PCR arrays (Array 1, top 84 hits;Array 2, top 85–164 genes) were used to measure...
<p>(A): Expression of the functional IFNφ1 (shIFNφ1) in cell lines. Gene expression was measured by ...
<p>NHBE (black bars) or NSBE (white bars) cells that reached a well-differentiated state were infect...
<p>NHBE (A) or NSBE (B) cells remaining in an undifferentiated state were infected at a MOI of 0.01 ...
<p>A) Undifferentiated NHBE and NSBE cells were left untreated or treated exogenously with 50 µg/ml ...
<p>A) Un-differentiated NHBE (open circles) and NSBE (closed triangles) cells were infected at a MOI...
<p>The qPCR fold-changes at 8 h, 18 h, 24 h, 48 h, and 72 h pi are shown for virus-infected dNSBE (l...
(A-B) Human colon organoids were stimulated with indicated concentrations of type I (β) or III IFN (...
<p>(<b>A</b>) Type I IFN locus, delimited to 400 kbps on human chromosome 9, consists of thirteen in...
<p>Expression of ISG15 (left), MX1 (middle) and OAS1 <a href="http://www.plosone.org/article/info:do...
<p>(A) The concentrations of the primary transcripts of the IFN-inducible genes indicated, and of GA...
<p>Two representative mice from four independent transgenic HyBNAR strains were injected IV. with 40...
<p>The relative amounts of IFN-β mRNA detected in the cells infected with the indicated viruses at 4...
<p>(A) Quantification of IFN-β mRNA levels by qRT-PCR during infection of CaCo-2 cells at a MOI of 1...
<p>MDCK cells were infected with the WT virus or MFPT<sup>r</sup> virus (clone 1) at 1 PFU/cell or m...
<p>Custom human qRT-PCR arrays (Array 1, top 84 hits;Array 2, top 85–164 genes) were used to measure...
<p>(A): Expression of the functional IFNφ1 (shIFNφ1) in cell lines. Gene expression was measured by ...
<p>NHBE (black bars) or NSBE (white bars) cells that reached a well-differentiated state were infect...
<p>NHBE (A) or NSBE (B) cells remaining in an undifferentiated state were infected at a MOI of 0.01 ...
<p>A) Undifferentiated NHBE and NSBE cells were left untreated or treated exogenously with 50 µg/ml ...
<p>A) Un-differentiated NHBE (open circles) and NSBE (closed triangles) cells were infected at a MOI...
<p>The qPCR fold-changes at 8 h, 18 h, 24 h, 48 h, and 72 h pi are shown for virus-infected dNSBE (l...
(A-B) Human colon organoids were stimulated with indicated concentrations of type I (β) or III IFN (...
<p>(<b>A</b>) Type I IFN locus, delimited to 400 kbps on human chromosome 9, consists of thirteen in...
<p>Expression of ISG15 (left), MX1 (middle) and OAS1 <a href="http://www.plosone.org/article/info:do...
<p>(A) The concentrations of the primary transcripts of the IFN-inducible genes indicated, and of GA...
<p>Two representative mice from four independent transgenic HyBNAR strains were injected IV. with 40...
<p>The relative amounts of IFN-β mRNA detected in the cells infected with the indicated viruses at 4...
<p>(A) Quantification of IFN-β mRNA levels by qRT-PCR during infection of CaCo-2 cells at a MOI of 1...
<p>MDCK cells were infected with the WT virus or MFPT<sup>r</sup> virus (clone 1) at 1 PFU/cell or m...
<p>Custom human qRT-PCR arrays (Array 1, top 84 hits;Array 2, top 85–164 genes) were used to measure...
<p>(A): Expression of the functional IFNφ1 (shIFNφ1) in cell lines. Gene expression was measured by ...