<p>HIV-1 Vpr induces HIF-1α that in turn induces HK and PKM2. Upregulation of HK expression on one hand results in conversion of glucose into glucose-6-phosphate (G6P) and forward feed into phosphoenolpyruvate (PEP) for conversion into pyruvate by PKM2 which then enters into mitochondria for conversion into Acetyl-CoA via the TCA cycle. On the other hand, HK can translocate to the outer mitochondrial membrane to confer an anti-apoptotic phenotype. Glucose, in addition can be metabolized by upregulation of Glucose-6-phosphate dehydrogenase (G6PD) via the pentose-phosphate pathway (PPP). In this pathway glucose-6-phosphate is decarboxylated to form ribose-5-phosphate (R5P) in a series of reaction involving 6-phosphogluconate dehydrogenase (6P...
Acquired immunodeficiency syndrome (AIDS) results from the dramatic loss of CD4+ T cells in human im...
Acquired immunodeficiency syndrome (AIDS) results from the dramatic loss of CD4+ T cells in human im...
HIV-1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible f...
<div><p>Human immunodeficiency virus type 1 encoded viral protein Vpr is essential for infection of ...
Human immunodeficiency virus type 1 encoded viral protein Vpr is essential for infection of macropha...
Human immunodeficiency virus type 1 encoded viral protein Vpr is essential for infection of macropha...
<p>Macrophage proteins within metabolic pathways altered in response to HIV-1 Vpr.</p
Abstract HIV‐1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir resp...
<p>Lipid classes are denoted by beige rectangles, enzymes are denoted by yellow rectangles with roun...
Mitochondria play a dual role in the life of the cell, being capable of producing either energy (in ...
HIV-1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible f...
HIV-1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible f...
Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic alterations of ...
HIV-1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible f...
<div><p>(A) pHR-VPR-G and pHR-VPR-R are bicistronic lentiviral vectors that encode HIV-1<sub>NL4–3 <...
Acquired immunodeficiency syndrome (AIDS) results from the dramatic loss of CD4+ T cells in human im...
Acquired immunodeficiency syndrome (AIDS) results from the dramatic loss of CD4+ T cells in human im...
HIV-1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible f...
<div><p>Human immunodeficiency virus type 1 encoded viral protein Vpr is essential for infection of ...
Human immunodeficiency virus type 1 encoded viral protein Vpr is essential for infection of macropha...
Human immunodeficiency virus type 1 encoded viral protein Vpr is essential for infection of macropha...
<p>Macrophage proteins within metabolic pathways altered in response to HIV-1 Vpr.</p
Abstract HIV‐1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir resp...
<p>Lipid classes are denoted by beige rectangles, enzymes are denoted by yellow rectangles with roun...
Mitochondria play a dual role in the life of the cell, being capable of producing either energy (in ...
HIV-1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible f...
HIV-1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible f...
Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic alterations of ...
HIV-1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible f...
<div><p>(A) pHR-VPR-G and pHR-VPR-R are bicistronic lentiviral vectors that encode HIV-1<sub>NL4–3 <...
Acquired immunodeficiency syndrome (AIDS) results from the dramatic loss of CD4+ T cells in human im...
Acquired immunodeficiency syndrome (AIDS) results from the dramatic loss of CD4+ T cells in human im...
HIV-1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible f...