Association of lipid classes with HIV infection and with future cardiovascular events in HIV infection mapped onto key metabolic pathways.

<p>Lipid classes are denoted by beige rectangles, enzymes are denoted by yellow rectangles with rounded edges, coloured arrows denote the various lipid metabolic pathways. The association with HIV infection is denoted by orange arrows and the association with future cardiovascular events in HIV is denoted by red arrows. Metabolite abbreviations: Cho, choline; DG, diacylglycerol; DHAP, dihydroxyacetonephosphate; Etn, ethanolamine; LPC, lysophosphatidylcholine; LPC O, lysoalkylphosphatidylcholine; LPE, lysophosphatidylethanolamine; PC, phosphatidylcholine; PC O, alkylphosphatidylcholine; PC P, alkenylphosphatidylcholine; PE, phosphatidylethanolamine; PE O, alkylphosphatidylethanolamine; PE P, alkenylphosphatidylethanolamine; PG, phosphatidylglycerol; PGP, phosphatidylglycerolphosphate; PI, phosphatidylinositol; TG, triacylglycerol. Enzyme abbreviations: A4GALT, lactosylceramide 4-alpha-galactosyltransferase; B4GALT6, beta-1,4-galactosyltransferase 6; CDIPT, CDP-diacylglycerol-inositol 3-phosphatidyltransferase; CDS1, phosphatidate cytidylyltransferase; CerS, ceramide synthasecls, cardiolipin synthase; CPT1, diacylglycerol cholinephosphotransferase; DEGS, sphingolipid delta-4 desaturase; DGAT, diacylglycerol O-acyltransferase; EPT1, diacylglycerol ethanolaminephosphotransferase; PEMT, phosphatidylethanolamine N-methyltransferase; ethanolaminephosphotransferase, pgpA, phosphatidylglycerophosphatase A; pgsA, CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase; PPAP2, phosphatidate phosphatase; SMGS, sphingomyelin synthase; UGCG, ceramide glucosyltransferase.