CD8+ T cell induced pathology requires specificity.

<p><i>Rag1−/−</i> mice were infected with <i>L. braziliensis</i> in the ear, and reconstituted with either WT or OT1 CD8+ T cells. (A) Ear thickness was evaluated at the site of infection. (B) Representative images of leishmanial lesions at 6 weeks post infection. At 7 weeks post infection mice were euthanized and shown are: (C) parasite burden in the lesions; (D) contour plots and (E) bar graph of CD107a expression by CD8+ T cells (pregated on: Live/Singlets/CD45+/CD8β+ cells). Graphs are representative data from one of two independent experiments (n = 3) with similar results. <i>*p<0.05.</i>