<p>CTCF binding levels and H3-K4/H3-K9 methylation in WT and UFM fibroblasts before (UT) and after <i>CTCF</i> depletion (siRNA) not followed by <i>FMR1</i> transcript reduction for the promoter and exon 1 regions, respectively. All values correspond to the mean amount of IP-DNA (ng)±standard deviation.</p>*<p>indicated statistically significant values (p<0.05).</p
<p>Top, scheme of DNA methylation analysis in the MYC promoter region. <i>Aci</i>I restriction enzym...
<p>(A) CTCF consensus motif used in this study <a href="http://www.plosgenetics.org/article/info:doi...
<p>(A) Open chromatin proximal to CTCF-binding sites in K562 cells. DNaseI HS, DNaseI DGF, and FAIRE...
<p>ChIP assay demonstrates the decrease of CTCF binding on <i>FMR1</i> promoter and exon 1 in WT fib...
<p>Bisulfite sequencing of 82 CpGs within the 5′-UTR of <i>FMR1</i> gene after <i>CTCF</i> knock-dow...
<p>ChIP assay of CTCF binding on <i>FMR1</i> promoter and exon 1 in WT, UFM and FXS cell lines, both...
<p>ChIP assay of CTCF binding to <i>FMR1</i> methylation boundary, promoter and exon 1 region after ...
<p>(<b>A</b>) Western blotting analysis of CTCF, visualized with ECL kit. Protein extracts from untr...
<p><i>CTCF</i> overexpression in WT, UFM and FXS cell lines after transfection with a commercial vec...
Fragile X syndrome (FXS), the leading cause of inherited intellectual disability, is caused by epige...
Fragile X syndrome (FXS), the leading cause of inherited intellectual disability, is caused by epige...
Fragile X syndrome (FXS), the leading cause of inherited intellectual disability, is caused by epige...
<p>(A) LMRs are bound by transcription factors (TF) and have intermediate average methylation levels...
<div><p>Fragile X syndrome (FXS), the leading cause of inherited intellectual disability, is caused ...
<p>A schematic outline of CTCF binding sites spanning the <i>FMR1</i> locus (white dot = unmethylate...
<p>Top, scheme of DNA methylation analysis in the MYC promoter region. <i>Aci</i>I restriction enzym...
<p>(A) CTCF consensus motif used in this study <a href="http://www.plosgenetics.org/article/info:doi...
<p>(A) Open chromatin proximal to CTCF-binding sites in K562 cells. DNaseI HS, DNaseI DGF, and FAIRE...
<p>ChIP assay demonstrates the decrease of CTCF binding on <i>FMR1</i> promoter and exon 1 in WT fib...
<p>Bisulfite sequencing of 82 CpGs within the 5′-UTR of <i>FMR1</i> gene after <i>CTCF</i> knock-dow...
<p>ChIP assay of CTCF binding on <i>FMR1</i> promoter and exon 1 in WT, UFM and FXS cell lines, both...
<p>ChIP assay of CTCF binding to <i>FMR1</i> methylation boundary, promoter and exon 1 region after ...
<p>(<b>A</b>) Western blotting analysis of CTCF, visualized with ECL kit. Protein extracts from untr...
<p><i>CTCF</i> overexpression in WT, UFM and FXS cell lines after transfection with a commercial vec...
Fragile X syndrome (FXS), the leading cause of inherited intellectual disability, is caused by epige...
Fragile X syndrome (FXS), the leading cause of inherited intellectual disability, is caused by epige...
Fragile X syndrome (FXS), the leading cause of inherited intellectual disability, is caused by epige...
<p>(A) LMRs are bound by transcription factors (TF) and have intermediate average methylation levels...
<div><p>Fragile X syndrome (FXS), the leading cause of inherited intellectual disability, is caused ...
<p>A schematic outline of CTCF binding sites spanning the <i>FMR1</i> locus (white dot = unmethylate...
<p>Top, scheme of DNA methylation analysis in the MYC promoter region. <i>Aci</i>I restriction enzym...
<p>(A) CTCF consensus motif used in this study <a href="http://www.plosgenetics.org/article/info:doi...
<p>(A) Open chromatin proximal to CTCF-binding sites in K562 cells. DNaseI HS, DNaseI DGF, and FAIRE...