<div><p>Expansion of myeloid-lineage leukocytes in tumor-bearing mice has been proposed as a cause of systemic immunosuppression. We demonstrate that radiation therapy of tumors leads to a decline in myeloid cell numbers in the blood and a decrease in spleen size. The frequency of myeloid cells does not decline to the level seen in tumor-free mice: we demonstrate that metastatic disease can prevent myeloid cell numbers from returning to baseline, and that tumor recurrence from residual disease correlates with re-expansion of myeloid lineage cells. Radiation therapy results in increased proliferation of T cells in the spleen and while T cell responses to foreign antigens are not altered by tumor burden or myeloid cell expansion, responses to...
Tumour development is accompanied by an enhanced haematopoiesis. This is not a widespread activation...
The immune system plays a vital role in cancer therapy, especially with the advent of immunotherapy....
It is now becoming clear that interactions between tumor cells and host tissue stoma play a key role...
Expansion of myeloid-lineage leukocytes in tumor-bearing mice has been proposed as a cause of system...
<p>a) i) Flow cytometry of fresh whole peripheral blood from naïve and 4T1 tumor-bearing BALB/c mice...
The discrepancy between the in vitro and in vivo response to radiation is readily explained by the f...
Radiation therapy is showing potential as a partner for immunotherapies in preclinical cancer models...
<p>a) Flow cytometry of fresh whole peripheral blood from i) naïve mice or mice bearing 4T1 tumors i...
Abstract Immunotherapy is a novel treatment approach for cancers; however, its therapeutic effects a...
Radiotherapy as a cancer treatment strategy is also known for its ability to modulate the immunogeni...
Radiotherapy as a cancer treatment strategy is also known for its ability to modulate the immunogeni...
Radiotherapy as a cancer treatment strategy is also known for its ability to modulate the immunogeni...
The immune system plays a vital role in cancer therapy, especially with the advent of immunotherapy....
The immune system plays a vital role in cancer therapy, especially with the advent of immunotherapy....
An accumulating body of evidence demonstrates that radiation therapy can generate adaptive immune re...
Tumour development is accompanied by an enhanced haematopoiesis. This is not a widespread activation...
The immune system plays a vital role in cancer therapy, especially with the advent of immunotherapy....
It is now becoming clear that interactions between tumor cells and host tissue stoma play a key role...
Expansion of myeloid-lineage leukocytes in tumor-bearing mice has been proposed as a cause of system...
<p>a) i) Flow cytometry of fresh whole peripheral blood from naïve and 4T1 tumor-bearing BALB/c mice...
The discrepancy between the in vitro and in vivo response to radiation is readily explained by the f...
Radiation therapy is showing potential as a partner for immunotherapies in preclinical cancer models...
<p>a) Flow cytometry of fresh whole peripheral blood from i) naïve mice or mice bearing 4T1 tumors i...
Abstract Immunotherapy is a novel treatment approach for cancers; however, its therapeutic effects a...
Radiotherapy as a cancer treatment strategy is also known for its ability to modulate the immunogeni...
Radiotherapy as a cancer treatment strategy is also known for its ability to modulate the immunogeni...
Radiotherapy as a cancer treatment strategy is also known for its ability to modulate the immunogeni...
The immune system plays a vital role in cancer therapy, especially with the advent of immunotherapy....
The immune system plays a vital role in cancer therapy, especially with the advent of immunotherapy....
An accumulating body of evidence demonstrates that radiation therapy can generate adaptive immune re...
Tumour development is accompanied by an enhanced haematopoiesis. This is not a widespread activation...
The immune system plays a vital role in cancer therapy, especially with the advent of immunotherapy....
It is now becoming clear that interactions between tumor cells and host tissue stoma play a key role...