Gross pathology of guinea pig organs infected with variou<i>s M.tuberculosis</i> strains at 10 weeks.

<p>The figure depicts representative photographs of gross pathological lesions and graphical depiction of gross scores of lung, liver and spleen of guinea pigs (n = 5) infected with <i>M.tuberculosis</i>, MtbΔ<i>sapM</i> and MtbΔ<i>sapM</i>Comp euthanized at 10 weeks post-infection. Each data point represents the score of an individual animal, and the bars depict medians (±interquartile range) for each group. Organs of the MtbΔ<i>sapM</i> infected animals exhibited fewer and smaller pulmonary, hepatic and splenic lesions when compared with the organs of guinea pigs infected with either <i>M.tuberculosis</i> or the MtbΔ<i>sapM</i>Comp. *, <i>P</i><0.05; **, <i>P</i><0.01 (Mann-Whitney U test).