Survival curves and skintest responses in <i>M. tuberculosis</i> infected guinea pigs.

<p>Survival curves of BCG vaccinated guinea pigs (triangles) and unvaccinated guinea pigs (open squares) after <i>M. tuberculosis</i> infection. The animals were sacrificed when they had lost 15% of the maximum weight or had clinical symptoms indicative of severe TB (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001978#pone-0001978-g001" target="_blank">Fig 1A</a>). Mean skin test reaction (+/−SEM) for <i>M. tuberculosis-</i>infected unimmunized and BCG vaccinated guinea pigs (n = 7), measured as erythema after intradermal injection of 2 ug E6/C10 (Fig. 1B) or 10 T.U. PPD (Fig. 1C). Each animal received a maximum of 4 tests with more than 8 weeks interval and this schedule did not sensitize naïve animals. The experiment was repeated twice with the same overall result and data shown for a representative experiment.