<i>In vitro</i> and <i>in vivo</i> radiation response of ALTS1C1 and SDFkd tumors.

<p>(A) The survival curve following IR was assayed by clonogenic assay. (B) Kaplan–Meier survival curves of ALTS1C1 and SDFkd tumor-bearing mice treated with various doses of irradiation. The arrow indicates the time (day 13 after brain tumor implantation) for which radiation was given. (C) The mean diameter of control and single-dose irradiated ALTS1C1 or SDFkd brain tumors measured at the maximum cross-section in H&E-stained tissues. * p<0.05. (D) Scatter plot of tumor islands in control and single-dose irradiated ALTS1C1 and SDFkd brain tumors. The invasive pattern was assessed in whole brain serial sections by DAPI staining. The plot represents the average island number of each brain in each group, as calculated using a microscope (× 100 power). * p<0.05, *** p<0.001.