Local brain irradiation prolonged the survival of tumor-bearing mice, but mice eventually died due to increased tumor.

<p>(A) Kaplan-Meier survival curves of ALTS1C1 glioma-bearing mice after 8 Gy or 15 Gy single-dose irradiation. The arrow indicates the time (day 13 after brain tumor implantation) at which radiation was given. (B) The mean diameter of control and irradiated ALTS1C1 brain tumors measured at the maximum cross-section in H&E-stained tissues. (C) Low-magnification merged image showing tumor invasion into the adjacent brain tissues. Scale bar = 1 mm. (D) Scatter plot of the invasion islands in the ALTS1C1 control and single-dose irradiated brain tumors. The invasive pattern was assessed in whole-brain serial sections by DAPI staining. The plot represents the average island number of each brain in each group, as calculated using a microscope (×100 power). * p<0.05.