Kidney/body weight ratios are increased in diabetic mice, without a significant difference between diabetic wildtype and heterozygous mice (Panel A).

<p>Representative kidney sections from non-diabetic wildtype [<b>B</b>] and CTGF heterozygous [<b>C</b>] and diabetic wildtype mouse [<b>D</b>] and diabetic CTGF heterozygous littermates [<b>E</b>] reveal increase in mesangial matrix is attenuated in diabetic CTGF heterozygous mice as compared to that observed in kidneys from wildtype animals. Panel <b>F</b> depicts estimated mesangial expansion score for the various groups. Kidneys were perfusion-fixed with PFA (4%), embedded in paraffin and sectioned (4 µm) followed by PAS staining. Original magnification ×200; *p<0.01; #p<0.05.