Representative renal histological findings from control FVB mice and from untreated and treated diabetic OVE26 mice.

<p>Shown are PAS- (<b>A, C, E</b>) and trichrome- (<b>B, D, F</b>) stained sections from control FVB mice (<b>A, B</b>) from vehicle-treated diabetic OVE26 mice (<b>C, D</b>), and from losartan-treated OVE26 mice (<b>E, F</b>). In contrast to non-diabetic mice which did nor show any renal pathology, diabetic mice displayed diffuse mesangial expansion (<b>C, E; arrow</b>). Tubulointerstitial fibrosis was not detectable at this stage of DM; however, trichrome blue stain was detected in the interstitial space in OVE26 mice (e.g., <b>D, arrowhead</b>), suggesting early accumulation of extracellular matrix material.