Comparison of Grb14^RA-PH-H-Ras structure with other RA domain-GTPase structures.

<p>(A) Stereo diagram of a superposition (aligned on Ras) of the structures (Cα traces) of Grb14^RA-PH-H-Ras and RalGDS^RA-H-Ras (PDB code 1LFD) [18]. Grb14^RA is colored green, RalGDS^RA is colored dark green, H-Ras is colored cyan (for Grb14^RA) or dark blue (for RalGDS^RA). Mg-GTP is shown bound to H-Ras in the Grb14^RA-PH structure. Select secondary-structure elements in the RA domains are labeled. (B) Stereo diagram of a superposition (aligned on Ras/Rap1) of the structures of Grb14^RA-PH-H-Ras and Raf1^RA-Rap1 (PDB code 1GUA) [26]. Raf1^RA is colored dark green and Rap1 is colored dark blue. Val88 of Raf1^RA is shown in stick and surface representation.