Statistical parametric map of dependence between episodic memory performance and demyelination.

<p>The brain regions with a voxel-wise positive linear dependence (<i>P</i><.05, FWE corrected) between MTR and the delayed cued recall in the RI-48 test for 69 subjects are rendered in different colors corresponding to different anatomical structures. For each brain region, a scatterplot of the MTR values of ten voxels with the highest values of the TFCE statistic are shown for sMCI (circles), mMCI (diamonds), and controls (crosses). The two upper images on the left show the involved parts of the splenium (in yellow) and of the posterior corona radiata (in green). The average (over the selected ten voxels) slope of the linear dependence is .13 for the splenium and .12 for the posterior corona radiata, while the average R² is .29 and .18, respectively. The third image (from the top) shows the dependence map in the white matter of the precuneus (in blue, the sagittal view). The average slope of the linear dependence is .16 and the average R² is .29 for the precuneus. The bottom brain image shows the longitudinal superior fasciculus, for which the average linear slope is .11 and the average R² is .14.