Structural covariance maps of the default mode network in autism and controls.

<p>Statistical parametric maps depict brain regions in which gray matter intensity covaried with that of the seed ROI (right PCC) in each group. (A) Structural covariance patterns appear robust in posterior brain regions, but restricted in frontal areas in autism (hot colors; see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0049172#pone-0049172-t002" target="_blank">Table 2</a>). Covariance outside of canonical DMN boundaries is also evidenced. (B) Corresponding scMRI map in normal controls corresponds to a robust canonical default mode network (cool colors). (C) scMRI maps from both groups overlaid on a single anatomic volume. scMRI data are T-statistic maps (p<0.01, FWE-corrected) displayed on the average anatomical template of all subjects. The left side of the image corresponds to the right side of the brain. DMN, default mode network; FWE, family-wise error; PCC, posterior cingulate cortex; ROI, region of interest; scMRI, structural covariance MRI.