<i>C.</i><i>albicans</i> genes analysis procedure diagram.

<p>The analysis of <i>C. albicans</i> was summarized in this figure, which includes the method used, key findings and the related Tables and Figures. First significant genes were first singled out by ANOVA and Bonferroni correction. GO analysis of these genes revealed that the key function is related to membrane transport. PCA showed that the infection can be classified into three stages according to gene expression profiles. K-mean clustering suggested that the genes profile can be cluster into two main groups: progressively expressed and progressively suppressed. Binomial tests were used to identify important GO-terms in the two main groups. For both total significant genes and cell surface-related genes, hyphal formation and cell wall reorganization demonstrated a significant association bias toward Group 1. Cellular homeostasis was found to demonstrate a significant bias toward Group 2, and most cell surface-realted genes in cellular homeostasis are iron related.