Effects of IDO deficiency on hepatic histopathology in the experimental mice.

<p>(A) and (B) H&E staining of liver sections from the experimental mice. (A) Representative photomicrographs of the liver sections of the IDO-WT mice and IDO-KO mice (low-power field). Black bar: 100 μm. (B) An enlarged photo (high-power field) of the liver sections from the IDO-WT mice. Ballooned hepatocytes (indicated by white arrows) and Mallory-Denk bodies (indicated by black arrows) were observed. Black bar: 20 μm. (C) The presence of NAS (steatosis, inflammation, and ballooning) was determined based on the histopathological analysis. The values are expressed as the mean ± SD. * <i>P</i> <0.001, ** <i>P</i> <0.05.