<p>(A) siRNA-mediated HNF4α (●) depletion or control siRNA (○) in mouse liver, (B) 10 days of oral EE (●) or vehicle (○) treatment in ovariectomized mice, (C) 14 days of T<sub>3</sub> (●) or vehicle treatment (○) and (D) mice fed with high (●) or low (○) fat diet for one day. Correlations were determined using Pearson correlation coefficient (r). <i>p</i>-values < 0.05 were regarded as statistically significant. <sup>‡</sup><i>p</i> < 0.001.</p
<p>Adult mice were pair-fed a high-fat diet (HFD) or low fat control diet (CTRL) with or without per...
<p>(A–C) Hepatic mRNA levels in <i>ob/ob</i> (A) and <i>db</i>/<i>db</i> mice (B) mice were determin...
<p>Expression of key genes involved in hepatic lipogenesis (A) and fatty acid oxidation (B) were mea...
<p>Relative transcript levels were quantified by TaqMan quantitative RT-PCR, normalized by β2MG and ...
<p>Quantitative RT-PCR analysis of relative mRNA levels for several genes related to lipid metabolis...
<p>Livers from siHNF4α injected animals (panel A, black bars) and siNEG injected animals as controls...
<p>Plasma FXI activity was measured under different metabolic conditions i.e siRNA-mediated depletio...
<p>mRNA levels of various cytokines and chemokines (<b>A and B</b>) and metabolic genes (<b>C and D<...
<p>Total RNA was extracted from livers as described in “<a href="http://www.plosone.org/article/info...
<div><p>Single nucleotide polymorphisms (SNPs) in a 4q35.2 locus that harbors the coagulation factor...
<p><b>A</b>: The correlation between the relative expression level of CYP3A and that of miR-shRNA1 d...
<p>Animals were treated as described in Methods.</p><p>All values are expressed as the mean ± SD; n ...
<p>Plasma levels of A) FGF21, C) IGF-1 and E) IGFBP-1 and relative hepatic mRNA expression levels of...
<p>Data are given as mean ± SD (n = 20, each genotype) in arbitrary units normalized to 18 S RNA con...
<p>Absolute expression levels from RNA-seq data in FPKM of dysregulated genes in the livers of Viv, ...
<p>Adult mice were pair-fed a high-fat diet (HFD) or low fat control diet (CTRL) with or without per...
<p>(A–C) Hepatic mRNA levels in <i>ob/ob</i> (A) and <i>db</i>/<i>db</i> mice (B) mice were determin...
<p>Expression of key genes involved in hepatic lipogenesis (A) and fatty acid oxidation (B) were mea...
<p>Relative transcript levels were quantified by TaqMan quantitative RT-PCR, normalized by β2MG and ...
<p>Quantitative RT-PCR analysis of relative mRNA levels for several genes related to lipid metabolis...
<p>Livers from siHNF4α injected animals (panel A, black bars) and siNEG injected animals as controls...
<p>Plasma FXI activity was measured under different metabolic conditions i.e siRNA-mediated depletio...
<p>mRNA levels of various cytokines and chemokines (<b>A and B</b>) and metabolic genes (<b>C and D<...
<p>Total RNA was extracted from livers as described in “<a href="http://www.plosone.org/article/info...
<div><p>Single nucleotide polymorphisms (SNPs) in a 4q35.2 locus that harbors the coagulation factor...
<p><b>A</b>: The correlation between the relative expression level of CYP3A and that of miR-shRNA1 d...
<p>Animals were treated as described in Methods.</p><p>All values are expressed as the mean ± SD; n ...
<p>Plasma levels of A) FGF21, C) IGF-1 and E) IGFBP-1 and relative hepatic mRNA expression levels of...
<p>Data are given as mean ± SD (n = 20, each genotype) in arbitrary units normalized to 18 S RNA con...
<p>Absolute expression levels from RNA-seq data in FPKM of dysregulated genes in the livers of Viv, ...
<p>Adult mice were pair-fed a high-fat diet (HFD) or low fat control diet (CTRL) with or without per...
<p>(A–C) Hepatic mRNA levels in <i>ob/ob</i> (A) and <i>db</i>/<i>db</i> mice (B) mice were determin...
<p>Expression of key genes involved in hepatic lipogenesis (A) and fatty acid oxidation (B) were mea...