Abnormal hippocampal lamination in the <i>Dcx-</i>KO mice.

<p>(A–B) NeuN labeled sagittal sections of adult hippocampus from a control (A) and a <i>Dcx</i>-KO (B) mouse showing a largely normal CA1 region but a disorganized CA3 region. This disorganization is characterized by two distinct pyramidal cell layers (termed <i>stratum pyramidale internal</i>, SPI, and <i>stratum pyramidale external,</i> SPE). (C) Histogram showing the distribution of pixel intensities along the red lines as indicated in A and B, across the CA3 region and extending from the <i>stratum radiatum</i> (sr) towards the <i>stratum oriens</i> (so) from both control (blue) and KO (red) mice. The distribution of these grey values clearly shows a double peak in the KOs corresponding to SPI and SPE respectively, in comparison to a single peak (corresponding to the <i>stratum pyramidal</i>, SP) in the WTs. Scale bar 60 µm.