The overlaid representative ¹H NMR spectra of urine (A) and serum (B) samples obtained from lean and obese mice.

<p>Black and red spectra are overlaid and shown for B6 mice and <i>ob</i>/<i>ob</i> mice, respectively. Samples from male and female mice are shown on the left and right, respectively. Each peak is labeled with the number that corresponds to the following metabolites. For urine samples (A), 1: pantothenate 2∶2-hydroxyisovalerate 3∶2-hydroxybutyrate 4∶2-hydroxyisobutyrate, lactate 5: alanine 6: acetate 7: N-acetyl aspartate 8: acetone 9: acetoacetate 10: succinate 11∶2-oxoisocaproate 12∶2-oxoglutarate 13: trimethylamine 14: methyl malonate 15: TMAO 16: taurine 17: creatinine 18: glycerol 19: guanidoacetate 20: pantothenate 21∶2-hydroxyvalerate 22: valine 23: isobutyrate 24: threonine 25: leucine 26: glutaric monomethyl ester 27: suberate 28: N-acetyal glutamate 29: methionine 30: pyruvate 31: methylamine 32: citrate 33∶5-aminolevulinate 34: dimethylamine 35: cis-aconitate 36: creatine 37: indole-3-acetate 38: choline 39: isopropanol 40: trigonelline. For serum samples (B), 1: VLDL/LDL cholesterol 2: isoleucine/leucine 3: valine 4: lactate 5: citrate 6: alanine 7: acetate 8: lysine 9: ornithine 10: TMAO 11: acetoacetate 12: glucose 13: ethylene glycol 14: alanine 15: glycolate 16: creatine 17: acetone 18: pyruvate 19: carnithine 20: methionine 21: phenylalanine 22: choline 23∶4-hydroxyphenylacetate 24: arginine 25: glycine 26: creatine 27: serine.