Effect of HspX and ESAT-6 on BCG-elicited DC maturation.

<p>DCs were treated with Mtb as a positive control and with BCG alone or combined with HspX and ESAT6. Cells were collected after 24(A) Histograms illustrate CD83, CD86 and HLA-DR surface expression in CD1a⁺ cells and the MFI. Filled histograms represent the control, open histograms indicate treated cells. One of four different experiments is presented. (B) Bar graphs show the CD83, CD86 and HLA-DR MFI value of the four experiments expressed as fold change (MFI FC) over control (CTRL). Statistical analysis: CTRL vs BCG alone; BCG alone vs BCG plus HspX and ESAT6; ns P>0.05, *P<0.05.