PECAM-directed Ab/SOD targeting to endothelial cells inhibits TNF-induced synthesis of VCAM.
- Vladimir V. Shuvaev (469634)
- Jingyan Han (469635)
- Samira Tliba (469636)
- Evguenia Arguiri (469637)
- Melpo Christofidou-Solomidou (469638)
- Servio H. Ramirez (283781)
- Holly Dykstra (283785)
- Yuri Persidsky (283794)
- Dmitriy N. Atochin (469639)
- Paul L. Huang (285377)
- Vladimir R. Muzykantov (171603)
Publication date
October 2013
DOIAbstract
<p>(A). Kinetics of synthesis of VCAM after endothelial cells induction by 10 ng/ml TNF as measured by qPCR. (B). Effects of Ab/SOD targeting. Cells were pretreated with anti-PECAM/SOD or untargeted SOD for 1 h and activated with 10 ng/ml TNF. Level of VCAM mRNA was measured by qPCR in 1 h. *p<0.05 vs. control. (Inset), representative Western blot analysis of VCAM protein after 5 h.</p
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