Proinfammatory cytokines are reduced in salicylate treated BBDR rats that remained diabetes-free.

<p>BBDR rats were untreated (vertical), pre-treated with pIC alone (hatched), H1+pIC (clear), KRV+pIC (black), or KRV+pIC+SS (diagonal). Serum samples were collected from rats at 1, 4, 7, and 11 days following KRV or H1 treatment and analyzed for (<b>A</b>) IL-1β. (<b>B</b>) IL-6, (<b>C</b>) IFN-γ, and (<b>D</b>) IL-12. Untreated control, n=3; mean values of control rats for IL-1β. IL-6, IFN-γ, and IL-12 were 1.85, 0.54, 2.07, and 0.47 ng/ml, respectively. For all treated groups, n≥6. Mean and standard error are shown; *p<0.05; **p<0.01; ***p<0.001.