NIF inhibits the diabetes-induced up-regulation of superoxide in retina but not circulating leukocytes.

<p>A) Superoxide generation increased in the retina of WT animals diabetic for 10 weeks, but not in diabetics expressing NIF (n=5). B) Superoxide production is increased also in leukocytes of WT animals diabetic 10 weeks compared to non-diabetic controls. In contrast, the presence of NIF resulted in an elevated leukocyte superoxide production in non-diabetic animals which was further increased in NIF mice diabetic for 10 weeks (n=5).