Involvement of H3 K56 deacetylation in the suppression of spontaneous mutagenesis in the yeast <i>S. cerevisiae</i>.

<p>Spontaneous mutation rates were measured as described in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003899#s4" target="_blank">Materials and Methods</a>. The data are shown as medians with 95% confidence intervals. The numbers above the bars are the relative mutation rates. (<b>A</b>) and (<b>B</b>) Effect of nicotinamide (NAM) on <i>CAN1</i> (<b>A</b>) and <i>his7-2</i> (<b>B</b>) mutation rates. The rates were measured in the haploid E134 strain (wild type) and indicated mutant derivatives exposed to 0-mM, 25-mM, or 50-mM NAM. (<b>C</b>) Effect of combining <i>hst3</i>Δ <i>hst4</i>Δ with <i>msh2</i>Δ, <i>mlh1</i>Δ, <i>pol2-4</i>, or <i>pol3-5DV</i> on spontaneous mutagenesis of <i>CAN1</i> and <i>his7-2</i>.