Intratumoral heterogeneity and variation among different patients for the expression of 4 exemplary proteins (VEGF, VEGFR, EGFR and p1068EGFR) assessed by reverse phase protein arrays.

Heterogeneity mapping of protein expression in tumors using quantitative immunofluorescence

Faratian, Dana
Christiansen, Jason
Gustavson, Mark
Jones, Christine
Scott, Christopher
Um, InHwa
Harrison, David J

October 2011

Morphologic heterogeneity within an individual tumor is well-recognized by histopathologists in surg...

An algorithm to quantify intratumor heterogeneity based on alterations of gene expression profiles: Data availability

Mengyuan Li
Zhilan Zhang
Lin Li
Xioasheng Wang

July 2020

DEPTH evaluates the tumor heterogeneity level of each tumor sample based on gene expression profiles...

Variation between 88 individual tumor samples from 13 patients assessed by non-supervised hierarchical clustering based on expression of 36 proteins.

Gabriele Mittermeyer (477284)
Katharina Malinowsky (149169)
Christian Beese (396376)
Heinz Höfler (137728)
Barbara Schmalfeldt (477285)
Karl-Friedrich Becker (71352)
Stefanie Avril (154632)

October 2013

Different patients are color-coded as indicated in the figure legend. High relative expression of...

Heterogeneity in the expression of 35 proteins assessed by reverse-phase-protein-arrays.

Katharina Malinowsky (149169)
Mithu Raychaudhuri (154628)
Theresa Buchner (154630)
Sabrina Thulke (154631)
Claudia Wolff (149167)
Heinz Höfler (137728)
Karl-Friedrich Becker (71352)
Stefanie Avril (154632)

July 2012

There was considerable intratumoral heterogeneity in the expression of all 35 proteins analyzed, ...

Common protein biomarkers assessed by reverse phase protein arrays show considerable intratumoral heterogeneity in breast cancer tissues. PLoS One 7: e40285

Katharina Malinowsky
Mithu Raychaudhuri
Theresa Buchner
Sabrina Thulke
Claudia Wolff
Karl-friedrich Becker
Stefanie Avril

January 2012

Proteins are used as prognostic and predictive biomarkers in breast cancer. However, the variability...

Common Protein Biomarkers Assessed by Reverse Phase Protein Arrays Show Considerable Intratumoral Heterogeneity in Breast Cancer Tissues

Katharina Malinowsky (149169)
Mithu Raychaudhuri (154628)
Theresa Buchner (154630)
Sabrina Thulke (154631)
Claudia Wolff (149167)
Heinz Höfler (137728)
Karl-Friedrich Becker (71352)
Stefanie Avril (154632)

July 2012

<div>Proteins are used as prognostic and predictive biomarkers in breast cancer. However, the var...

Variation in Cell Signaling Protein Expression May Introduce Sampling Bias in Primary Epithelial Ovarian Cancer

Gabriele Mittermeyer
Katharina Malinowsky
Christian Beese
Barbara Schmalfeldt

August 2016

Although the expression of cell signaling proteins is used as prognostic and predictive biomarker, v...

Comparison of intratumoral heterogeneity and variation among patients for all proteins, phosphorylated and non-phosphorylated proteins.

Gabriele Mittermeyer (477284)
Katharina Malinowsky (149169)
Christian Beese (396376)
Heinz Höfler (137728)
Barbara Schmalfeldt (477285)
Karl-Friedrich Becker (71352)
Stefanie Avril (154632)

October 2013

CV, coefficient of variation.Overall, all proteins combined; Phospho, all phosphorylated p...

Variation in cell signaling protein expression may introduce sampling bias in primary epithelial ovarian cancer.

Mittermeyer, G.
Malinowsky, K.
Beese, C.
Höfler, H.
Schmalfeldt, B.
Becker, K.F.
Avril, S.

January 2013

Although the expression of cell signaling proteins is used as prognostic and predictive biomarker, v...

Box plots for mRNA levels of different metabolizing genes of meningiomas and astrocytomas.

Pantelis Stavrinou (828030)
Maria-Christina Mavrogiorgou (828031)
Konstantinos Polyzoidis (828032)
Vincenzo Kreft-Kerekes (828033)
Marco Timmer (828034)
Marios Marselos (828035)
Periklis Pappas (828036)

November 2015

The line represents the median; boxes, 25% and 75% percentiles; whiskers, 1.5 times the box size....

Box plot showing the plasma levels of each differentially expressed protein in GBM plasma (n = 14) compared with healthy plasma (n = 15).

Eisuke Miyauchi (1442785)
Takuya Furuta (3846844)
Sumio Ohtsuki (265857)
Masanori Tachikawa (331224)
Yasuo Uchida (733510)
Hemragul Sabit (4919599)
Wataru Obuchi (4919602)
Tomoko Baba (515281)
Michitoshi Watanabe (3747013)
Tetsuya Terasaki (265859)
Mitsutoshi Nakada (89233)

March 2018

Each dot represents the protein level of an individual sample. In box plots, the band inside the ...

Comparison of protein concentrations in different regions of the tumor.

Kristian Sexton (402212)
Kenneth Tichauer (402213)
Kimberley S. Samkoe (402214)
Jason Gunn (402215)
P. Jack Hoopes (402216)
Brian W. Pogue (402217)

April 2013

Concentrations are calculated as described in equation (1). The percentage of protein that is Aff...

A representative example of intratumoral EGFR genetic heterogeneity.

Hua Bai (145775)
Zhijie Wang (283745)
Yuyan Wang (283747)
Minglei Zhuo (283748)
Qinghua Zhou (103187)
Jianchun Duan (283751)
Lu Yang (30847)
Meina Wu (283753)
Tongtong An (283754)
Jun Zhao (59250)
Jie Wang (16762)

February 2013

The left graph showed routine EGFR mutation status detection by DHPLC and corresponding bulk tiss...

Clustering and Venn Diagram of Significant Proteins (q-value <0.20).

Linan Wang (1428307)
Owen E. Branson (1317666)
Konstantin Shilo (344808)
Charles L. Hitchcock (3159585)
Michael A. Freitas (141119)

November 2016

A. Unsupervised clustering of the 35 individual thymus samples reveal distinctive clusteri...

Expression variability in matched cancer vs. normal tissue.

Christy L. Trejo (6392345)
Miloš Babić (6392348)
Elliot Imler (6392351)
Migdalia Gonzalez (6392354)
Sergei I. Bibikov (6392357)
Peter J. Shepard (701801)
Harper C. VanSteenhouse (4047664)
Joanne M. Yeakley (4047661)
Bruce E. Seligmann (4047670)

February 2019

Reproducibility of within-donor biological replicates (average of three technical replicates each) o...

Heterogeneity mapping of protein expression in tumors using quantitative immunofluorescence

Faratian, Dana
Christiansen, Jason
Gustavson, Mark
Jones, Christine
Scott, Christopher
Um, InHwa
Harrison, David J

October 2011

Morphologic heterogeneity within an individual tumor is well-recognized by histopathologists in surg...

An algorithm to quantify intratumor heterogeneity based on alterations of gene expression profiles: Data availability

Mengyuan Li
Zhilan Zhang
Lin Li
Xioasheng Wang

July 2020

DEPTH evaluates the tumor heterogeneity level of each tumor sample based on gene expression profiles...

Variation between 88 individual tumor samples from 13 patients assessed by non-supervised hierarchical clustering based on expression of 36 proteins.

Gabriele Mittermeyer (477284)
Katharina Malinowsky (149169)
Christian Beese (396376)
Heinz Höfler (137728)
Barbara Schmalfeldt (477285)
Karl-Friedrich Becker (71352)
Stefanie Avril (154632)

October 2013

Different patients are color-coded as indicated in the figure legend. High relative expression of...

Heterogeneity in the expression of 35 proteins assessed by reverse-phase-protein-arrays.

Katharina Malinowsky (149169)
Mithu Raychaudhuri (154628)
Theresa Buchner (154630)
Sabrina Thulke (154631)
Claudia Wolff (149167)
Heinz Höfler (137728)
Karl-Friedrich Becker (71352)
Stefanie Avril (154632)

July 2012

There was considerable intratumoral heterogeneity in the expression of all 35 proteins analyzed, ...

Common protein biomarkers assessed by reverse phase protein arrays show considerable intratumoral heterogeneity in breast cancer tissues. PLoS One 7: e40285

Katharina Malinowsky
Mithu Raychaudhuri
Theresa Buchner
Sabrina Thulke
Claudia Wolff
Karl-friedrich Becker
Stefanie Avril

January 2012

Proteins are used as prognostic and predictive biomarkers in breast cancer. However, the variability...

Common Protein Biomarkers Assessed by Reverse Phase Protein Arrays Show Considerable Intratumoral Heterogeneity in Breast Cancer Tissues

Katharina Malinowsky (149169)
Mithu Raychaudhuri (154628)
Theresa Buchner (154630)
Sabrina Thulke (154631)
Claudia Wolff (149167)
Heinz Höfler (137728)
Karl-Friedrich Becker (71352)
Stefanie Avril (154632)

July 2012

<div>Proteins are used as prognostic and predictive biomarkers in breast cancer. However, the var...

Variation in Cell Signaling Protein Expression May Introduce Sampling Bias in Primary Epithelial Ovarian Cancer

Gabriele Mittermeyer
Katharina Malinowsky
Christian Beese
Barbara Schmalfeldt

August 2016

Although the expression of cell signaling proteins is used as prognostic and predictive biomarker, v...

Comparison of intratumoral heterogeneity and variation among patients for all proteins, phosphorylated and non-phosphorylated proteins.

Gabriele Mittermeyer (477284)
Katharina Malinowsky (149169)
Christian Beese (396376)
Heinz Höfler (137728)
Barbara Schmalfeldt (477285)
Karl-Friedrich Becker (71352)
Stefanie Avril (154632)

October 2013

CV, coefficient of variation.Overall, all proteins combined; Phospho, all phosphorylated p...

Variation in cell signaling protein expression may introduce sampling bias in primary epithelial ovarian cancer.

Mittermeyer, G.
Malinowsky, K.
Beese, C.
Höfler, H.
Schmalfeldt, B.
Becker, K.F.
Avril, S.

January 2013

Although the expression of cell signaling proteins is used as prognostic and predictive biomarker, v...

Box plots for mRNA levels of different metabolizing genes of meningiomas and astrocytomas.

Pantelis Stavrinou (828030)
Maria-Christina Mavrogiorgou (828031)
Konstantinos Polyzoidis (828032)
Vincenzo Kreft-Kerekes (828033)
Marco Timmer (828034)
Marios Marselos (828035)
Periklis Pappas (828036)

November 2015

The line represents the median; boxes, 25% and 75% percentiles; whiskers, 1.5 times the box size....

Box plot showing the plasma levels of each differentially expressed protein in GBM plasma (n = 14) compared with healthy plasma (n = 15).

Eisuke Miyauchi (1442785)
Takuya Furuta (3846844)
Sumio Ohtsuki (265857)
Masanori Tachikawa (331224)
Yasuo Uchida (733510)
Hemragul Sabit (4919599)
Wataru Obuchi (4919602)
Tomoko Baba (515281)
Michitoshi Watanabe (3747013)
Tetsuya Terasaki (265859)
Mitsutoshi Nakada (89233)

March 2018

Each dot represents the protein level of an individual sample. In box plots, the band inside the ...

Comparison of protein concentrations in different regions of the tumor.

Kristian Sexton (402212)
Kenneth Tichauer (402213)
Kimberley S. Samkoe (402214)
Jason Gunn (402215)
P. Jack Hoopes (402216)
Brian W. Pogue (402217)

April 2013

Concentrations are calculated as described in equation (1). The percentage of protein that is Aff...

A representative example of intratumoral EGFR genetic heterogeneity.

Hua Bai (145775)
Zhijie Wang (283745)
Yuyan Wang (283747)
Minglei Zhuo (283748)
Qinghua Zhou (103187)
Jianchun Duan (283751)
Lu Yang (30847)
Meina Wu (283753)
Tongtong An (283754)
Jun Zhao (59250)
Jie Wang (16762)

February 2013

The left graph showed routine EGFR mutation status detection by DHPLC and corresponding bulk tiss...

Clustering and Venn Diagram of Significant Proteins (q-value <0.20).

Linan Wang (1428307)
Owen E. Branson (1317666)
Konstantin Shilo (344808)
Charles L. Hitchcock (3159585)
Michael A. Freitas (141119)

November 2016

A. Unsupervised clustering of the 35 individual thymus samples reveal distinctive clusteri...

Expression variability in matched cancer vs. normal tissue.

Christy L. Trejo (6392345)
Miloš Babić (6392348)
Elliot Imler (6392351)
Migdalia Gonzalez (6392354)
Sergei I. Bibikov (6392357)
Peter J. Shepard (701801)
Harper C. VanSteenhouse (4047664)
Joanne M. Yeakley (4047661)
Bruce E. Seligmann (4047670)

February 2019

Reproducibility of within-donor biological replicates (average of three technical replicates each) o...

Heterogeneity mapping of protein expression in tumors using quantitative immunofluorescence

Faratian, Dana
Christiansen, Jason
Gustavson, Mark
Jones, Christine
Scott, Christopher
Um, InHwa
Harrison, David J

October 2011

Morphologic heterogeneity within an individual tumor is well-recognized by histopathologists in surg...

An algorithm to quantify intratumor heterogeneity based on alterations of gene expression profiles: Data availability

Mengyuan Li
Zhilan Zhang
Lin Li
Xioasheng Wang

July 2020

DEPTH evaluates the tumor heterogeneity level of each tumor sample based on gene expression profiles...

Variation between 88 individual tumor samples from 13 patients assessed by non-supervised hierarchical clustering based on expression of 36 proteins.

Gabriele Mittermeyer (477284)
Katharina Malinowsky (149169)
Christian Beese (396376)
Heinz Höfler (137728)
Barbara Schmalfeldt (477285)
Karl-Friedrich Becker (71352)
Stefanie Avril (154632)

October 2013

Different patients are color-coded as indicated in the figure legend. High relative expression of...

Intratumoral heterogeneity and variation among different patients for the expression of 4 exemplary proteins (VEGF, VEGFR, EGFR and p1068EGFR) assessed by reverse phase protein arrays.

Abstract

Extracted data

Intratumoral heterogeneity and variation among different patients for the expression of 4 exemplary proteins (VEGF, VEGFR, EGFR and p1068EGFR) assessed by reverse phase protein arrays.

Abstract

Extracted data

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