General scheme for synthesis of compound 8.
- Priyankar Sanphui (482316)
- Sumit Kumar Pramanik (482317)
- Nandini Chatterjee (482318)
- Ponnusamy Moorthi (482319)
- Biswadip Banerji (482320)
- Subhas Chandra Biswas (482321)
Publication date
November 2013
DOIAbstract
<p>Reagent and conditions: (a) Conc. H<sub>2</sub>SO<sub>4</sub>, MeOH, 0°C to rt, 6 hrs. (b) Triethylamine(1.5 equiv.), THF, 0°C - r.t., 4 hrs. (c) SnCl<sub>2</sub> (3.0 equiv.), ethanol, reflux, 2 hrs, (d) NaNO<sub>2</sub>(aq), HCl-AcOH, 0°C, 0.5 hrs. (e) Cu powder, 70°C. (f) Lithium hydroxide (1.5 equiv.), MeOH-water (5∶1), 0°C to rt, 1.5 hrs. (g) EDC.HCl (1.5 equiv.), HOBT (1.2 equiv.), TEA (3 equiv.), 0°C to rt, 7.0 hrs. (h) 4(M) HCl in 1,4 dioxane, 0°C to rt, 2.0 hrs.</p
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