CD4⁺/CD8⁺CD25⁺FOXP3⁻ and CD4⁺/CD8⁺CD25⁻FOXP3⁻ frequency in leprosy patients and contacts.

<p>The frequency of CD4⁺/CD8⁺CD25⁺FOXP3⁻ and CD4⁺/CD8⁺CD25⁻FOXP3⁻ cells in CD4⁺ or CD8⁺ lymphocyte gate after 72-hour culture of peripheral blood mononuclear cells with anti-CD3 and anti-CD28 associated with total sonicated fraction of <i>M. leprae.</i> Comparison between household contacts (HHC), multibacillary patients (MB P) and paucibacillary patients (PB P), with regard to frequency of CD4⁺CD25⁺FOXP3⁻ (A), CD8⁺CD25⁺FOXP3⁻ (B), CD4⁺CD25⁻FOXP3⁻ (C) and CD8⁺CD25⁻FOXP3⁻ (D) cells. Unpaired two-tailed Student t-test, <i>p</i>≤0.05 was considered significant. Results are presented as mean with SD.